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Never, donepezil is the world's infiltrate-selling Alzheimer's drug -Maintenance dose: 23 mg orally once a day, after the patient has been on a dose of 10 mg once a day for at least 3 months Comments: A higher dose of 10 mg may or may not provide a statistically significantly greater clinical benefit than a 5 mg dose. It's taken as a pill once a day or as an extended release capsule twice a day.. Donepezil (Aricept®; Eisai Inc. To view the price of the drug, click on the. On its face, the choice of 23 mg as the dose rather than 20 mg is curious.. Following a one month clinical assessment of treatment at 5 mg/day, the dose of Aricept can be increased to 10 mg/day (once-a-day dosing) View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions. 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